Gambogenic acid

Name	Gambogenic acid
Synonyms	Gambogenic acid (2Z)-4-[(1R,3aS,5S,12aS)-9-[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]-3a,4,5,7-tetrahydro-8,10-dihydroxy-3,3-dimethyl-11-(3-methyl-2-buten-1-yl)-7,13-dioxo-1,5-methano-1H,3H-furo[3,4-d]xanthen-1-yl]-2-methyl-2-butenoic acid 2-Butenoic acid, 4-[(1R,3aS,5S,12aS)-9-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-3a,4,5,7-tetrahydro-8,10-dihydroxy-3,3-dimethyl-11-(3-methyl-2-buten-1-yl)-7,13-dioxo-1,5-methano-1H,3H-furo[3,4-d]xanthen-1-yl]-2-methyl-, (2Z)-
CAS	173932-75-7

Molecular Formula	C38H46O8
Molar Mass	630.78
Density	1.27±0.1 g/cm3(Predicted)
Boling Point	818.6±65.0 °C(Predicted)
pKa	4.58±0.36(Predicted)
Physical and Chemical Properties	Brown red crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Garcinia.

biological activity	gambiogenic acid is an active ingredient in Huangteng, which has anti-cancer activity. Gambosogenic acid is a potent EZH2 inhibitor that specifically binds covalently to the Cys668 site of the EZH2-SET domain, inducing EZH2 ubiquitination.
Target	Value
Use	neogambogic acid has anti-tumor and anti-cancer effects.

Last Update：2024-04-09 21:04:16

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Gambogenic acid

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